Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

MyoTumour

Financiado

A novel role for skeletal muscle in tumour growth and proliferation

Cachexia is a life-threatening condition characterized by a drastic loss in both muscle and adipose tissue, which is associated with several pathologies, including cancer. In cancer patients, its prevalence is of 50-80%, and is th... ver más

30/06/2026

VIMM

173K€

Presupuesto del proyecto: 173K€

Líder del proyecto

FONDAZIONE PER LA RICERCA BIOMEDICA AVANZATA... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 2 Participantes

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-05-07

HORIZON-MSCA-2023-PF-01-01: MSCA Postdoctoral Fellowships 2023 ExpectedOutcome:Project results are expected to contribute to the following outcomes:

I+D

Cerrada hace 1 año

0% 100% 100%

2 Participantes

VIMM

172.75K€ | Lider

UNIPD

172.75K€ | Participante

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

SAF2015-65589-P REGULACION DE LA CONVERSION DEL TEJIDO ADIPOSO BLANCO EN MAR... 202K€ Cerrado

SAF2008-02284 MIOSTATINA Y CAQUEXIA CANCEROSA: PERDIDA DE MASA MUSCULAR Y... 109K€ Cerrado

SAF2011-26091 TERAPIA COMBINADA COMO ESTRATEGIA PARA EL TRATAMIENTO DE LA... 109K€ Cerrado

MIEXIA Mitochondria-Inflammation crosstalk and EXercise-induced pat... 231K€ Cerrado

PGC2018-101899-B-I00 RESPUESTA DEL SISTEMA INMUNE INNATO FRENTE A METASTASIS PERI... 321K€ Cerrado

SAF2015-69221-R PIT-1, VITAMINA D Y ESTROMA EN CANCER DE MAMA 133K€ Cerrado

Duración del proyecto: 25 meses Fecha Inicio: 2024-05-07
Fecha Fin: 2026-06-30

Líder del proyecto

FONDAZIONE PER LA RICERCA BIOMEDICA AVANZATA... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 173K€

Descripción del proyecto Cachexia is a life-threatening condition characterized by a drastic loss in both muscle and adipose tissue, which is associated with several pathologies, including cancer. In cancer patients, its prevalence is of 50-80%, and is the direct cause of at least 20% of cancer-associated deaths. Cachectic patients show lower response rates to chemotherapy and a reduced tolerance to anticancer treatment, being of major clinical relevance. So, while cachexia is clearly of great significance for disease prognosis and survival in general, it is mainly considered a consequence of the presence of the tumour. Tumour-induced muscle wasting is due to the development of anabolic resistance, which is the impaired ability of nutrition and exercise to stimulate muscle protein synthesis. There have been results, however, which suggest that prevention or reverting muscle mass can lead to significant improvements of survival and overall well-being of tumour-bearing animals. While these results are suggestive of an important role for skeletal muscle, whether or not this is due to a direct effect on tumour biology is not well-established. The proposed project is based on preliminary results showing that tumour growth and proliferation are affected by activating the anabolic kinase Akt specifically in skeletal muscle in vivo, suggestive of muscle-tumour crosstalk. Follow up experiments performed using a microfluidics system showed that this effect is likely mediated by factors directly released by skeletal muscles, and not through indirect effects, like altering food intake or modulation of the immune system. In the current project, we propose to confirm and further decipher the muscle-tumour crosstalk in vivo. Subsequently, we propose to identify muscle-secreted factors with a microfluidics approach analyzing their effect on multiple tumour cell lines.

Conecta tu I+D

Entra hoy

¿Olvidó su contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores