NemHostRangeParadox
Financiado
A nematode host range paradox how can one of the apparently most specialised ob...
A nematode host range paradox how can one of the apparently most specialised obligate biotrophic plant parasites also have the largest host rangeNemHostRangeParadoxA nematode h
The root-knot nematode (Meloidogyne incognita) is an obligate biotrophic pathogen with a remarkable ability to deliver effector molecules into its host plant, allowing it to reproducibly and exquisitely alter plant immunity, devel...
The root-knot nematode (Meloidogyne incognita) is an obligate biotrophic pathogen with a remarkable ability to deliver effector molecules into its host plant, allowing it to reproducibly and exquisitely alter plant immunity, development, and physiology. Paradoxically, this nematode also has the widest host range of any obligate biotroph: parasitizing more than 3,000 different species. I hypothesize that the polyploid nature of its genome allows it to harbor an effector repertoire that not only allows for this broad host range, but its differentially deployed across its host range. To address this hypothesis, we have carefully pre-selected plant species across the botanical orders covering the main groups across the phylum. We will infect each species with M. incognita and, in a trans-kingdom linked transcriptome we will analysed nematode gene expression, and plant gene expression, at the same time in each susceptible interaction. These data will allow us to determine: 1) Is there a core set of effectors that are invariantly deployed, independent of host, and/or are subsets chosen for particular hosts or groups of hosts?; 2) Are there conserved plant genes manipulated by M. incognita during the infection?; and 3) Finally, are some plant or nematode genes required for specific interactions or group of interactions? These data will allow us to address a long-standing question in the field, and I believe understanding how M. incognita can infect such a broad host range may be a key to future control.
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Duración del proyecto: 29 meses
Fecha Inicio: 2021-04-19
Fecha Fin: 2023-09-30
Fecha Fin: 2023-09-30
Línea de financiación: concedida
El organismo H2020 notifico la concesión del proyecto el día 2023-09-30
Línea de financiación objetivo
El proyecto se financió a través de la siguiente ayuda:
MSCA-IF-2020:
Individual Fellowships
Cerrada
hace 4 años
Presupuesto
El presupuesto total del proyecto asciende a
225K€
Líder del proyecto
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Perfil tecnológico
TRL
4-5
Perfil tecnológico
TRL
4-5
216.34K€ |
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