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PLAST_CELL

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A multiplexed biomimetic imaging platform for assessing single cell plasticity (...

A multiplexed biomimetic imaging platform for assessing single cell plasticity (Plastomics) and scoring of tumour malignancy Metastasis is the major cause of death in cancer patients due to cancer cell dissemination to distant organs. Cell plasticity is a core characteristic of metastatic cells and confers cellular adaptation capabilities to variable me... ver más

30/04/2026

FUNDACIO PRIVADA C...

3M€

Presupuesto del proyecto: 3M€

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FUNDACIO PRIVADA CENTRE DE REGULACIO GENOMICA Otras actividades deportivas asociacion

TRL 4-5 | 50K€

Fecha límite participación Sin fecha límite de participación.

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Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2022-03-24

HORIZON-EIC-2021-PATHFINDEROPEN-01-01: EIC Pathfinder Open 2021 Scope:You should apply to this call if you are looking for support from EIC Pathfinder Open to reali...

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5 Participantes

FUNDACIO PRIVADA CENTRE DE R...

1.11M€ | Lider

CHERRY BIOTECH

472.44K€ | Participante

EMBL

358.89K€ | Participante

FUNDACIO INSTITUT DE CIENCIE...

375.25K€ | Participante

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Duración del proyecto: 49 meses Fecha Inicio: 2022-03-24
Fecha Fin: 2026-04-30

Líder del proyecto

FUNDACIO PRIVADA CENTRE DE REGULACIO GENOMICA Otras actividades deportivas asociacion

TRL 4-5 | 50K€

Presupuesto del proyecto 3M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Metastasis is the major cause of death in cancer patients due to cancer cell dissemination to distant organs. Cell plasticity is a core characteristic of metastatic cells and confers cellular adaptation capabilities to variable mechano-chemical tissue microenvironments. However, to date, specific quantitative measures of cancer cell plasticity associated with tumour aggressiveness and therapy resistance have remained difficult to establish. A major limitation is the availability of highthroughput multiplexed assays that can capture phenotypic heterogeneity and morphodynamic plasticity at the single cell level in standardized 3D culture conditions reflecting in vivo tissue microenvironments. The PLAST_CELL interdisciplinary consortium will pioneer the development of a microfluidics-based imaging platform to categorize and score cancer cell plasticity within diverse physiologically relevant 3D biomimetic culture conditions. The platform will enable to perform single cell multi-scale morphometric and molecular live cell data collection (PLAST_DATA) with minimal sample size (<10k cells). Data will be generated based on single molecule-sensitivity marker detection and cellular/subcellular morphodynamic feature recognition via minimal-invasive long-term super-resolution microscopy and parallel morphodynamic imaging of cellular behaviour. Computational integration of PLAST_DATA using preclinical models and patient samples will enable to develop a quantitative classification of tumour cell plasticity and predictive scoring of cancer aggressiveness, metastasis and drug resistance (PLAST_SCORE). The ability to assess cell plasticity based on cellular behaviours is beyond current clinical parameters and will strongly impact diagnosis, prognosis and treatments. The PLAST_CELL platform will be a technology breakthrough to establish new quantitative standards to evaluate cell plasticity and mechanisms of tumour malignancy for a new era of basic research and personalized medicine.

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