Innovating Works

HEALIKICK

Financiado
A modular strategy for the repair of critical sized bone fractures
Disruptive technologies for bone regeneration must be able to tackle complex fracture environments which have developed into non-union bone defects. These types of fracture are common and increasingly prevalent when considering th... Disruptive technologies for bone regeneration must be able to tackle complex fracture environments which have developed into non-union bone defects. These types of fracture are common and increasingly prevalent when considering the rise in osteoporosis cases. Bioengineered bone graft systems need to be able to guide the regrowth of new bone into substantial voids and therefore implants pre-seeded with mineralising cells are of significant clinical interest. We will implement a surgical co-administration of two robust technologies 1) a granular graft material with a highly osteogenic coating that presents relevant biologics very efficiently and 2) pre-differentiated osteogenic adipose mesenchymal stromal cells (MSCs) that together will underpin efficient bone regeneration. Within the project we aim to take these two technologies into GMP and ISO rated manufacture as required for any clinical therapy. We will then implement these therapies in pre-clinical studies to obtain efficacy and safety data to support a full clinical trial application. The novel technologies will be developed into a new medical device and a new cellular therapy with pre-clinical validation for their co-administration. This modular application of two highly advanced therapies is itself highly novel in terms of clinical strategy and by the end of the project we aim to have made the required regulatory and technical developments to submit them for clinical trial. In parallel to the core therapy we will expand the therapeutic pipeline by replacing the granular graft with 3D printed polymeric scaffold, again including including a highly osteogeneic coating, as a carrier for the cell therapy. Targeting even larger bone defects, this scaffold will be co-administered with the cellular therapy in pre-clinical efficacy studies. ver más
31/05/2025
UNIVERSITY OF GLAS...
5M€
Duración del proyecto: 60 meses Fecha Inicio: 2020-05-04
Fecha Fin: 2025-05-31

Línea de financiación: concedida

El organismo H2020 notifico la concesión del proyecto el día 2020-05-04
Línea de financiación objetivo El proyecto se financió a través de la siguiente ayuda:
SC1-BHC-07-2019: Regenerative medicine: from new insights to new applications
Cerrada hace 5 años
Presupuesto El presupuesto total del proyecto asciende a 5M€
Líder del proyecto
UNIVERSITY OF GLASGOW No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico TRL 4-5