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LEAP

Financiado

A leaky evidence accumulation process (LEAP) for consciousness

How we consciously experience the world remains a mystery in science. To tackle this problem, scientific works on perceptual consciousness contrast brain activity when participants consciously perceive a stimulus versus when they... ver más

30/09/2028

INSERM

1M€

Presupuesto del proyecto: 1M€

Líder del proyecto

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHER... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Ver 3 Participantes

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-02-20

ERC-2022-STG: ERC STARTING GRANTS Scope:Objectives

I+D

Cerrada hace 2 años

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3 Participantes

INSERM

1.50M€ | Lider

UGA

N.D. | Participante

CHU

N.D. | Participante

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Duración del proyecto: 67 meses Fecha Inicio: 2023-02-20
Fecha Fin: 2028-09-30

Líder del proyecto

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHER... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 1M€

Descripción del proyecto How we consciously experience the world remains a mystery in science. To tackle this problem, scientific works on perceptual consciousness contrast brain activity when participants consciously perceive a stimulus versus when they are unaware of it. To report stimulus awareness, participants need to make decisions. However, the extent to which the well-studied mechanisms of decision-making apply to consciousness is unclear. One possible reason is that standard neuroimaging methods lack the sensitivity to observe whether the mechanisms of decision-making also operate in the absence of task relevance, as when participants become conscious of a stimulus irrespective of any task. In this project, I will test the hypothesis that a mechanism of decision-making –evidence accumulation– explains how perceptual consciousness unfolds over time. First, I will develop a computational model of a latent evidence accumulation process (LEAP) and test it on behavioral measures of phenomenal aspects of perceptual experience: its duration and intensity. Second, I will search for single neuron activity in humans that instantiates evidence accumulation and test whether it also determines these phenomenal aspects of perceptual experience. Third, I will stimulate the corresponding brain regions to disentangle their causal role in either solely triggering perceptual experience or shaping it. Last, I will use the LEAP model to explain hallucinatory-like experiences in patients with Parkinson's disease and test whether deep-brain stimulation affects only decision-making –as previously shown– or also perceptual experience. By combining computational modeling and cutting-edge electrophysiology, the LEAP project will provide unique mechanistic insights on how neuronal activity determines perceptual experience and guides its temporal dynamics. It will also provide a tool to better understand hallucinations, which remain today a major debilitating symptom in numerous psychiatric disorders.

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