SYNERGISTIC
Financiado
A direct photocatalytic access to chiral β2-amino acids from alkenes using CO2 a...
A direct photocatalytic access to chiral β2-amino acids from alkenes using CO2 as the carbon source
The development of enantioselective strategies is becoming highly important as the global chiral chemicals market is expected to reach 120 billion USD by 2025. Among these chiral molecules, β2-amino acids and their derivatives are...
The development of enantioselective strategies is becoming highly important as the global chiral chemicals market is expected to reach 120 billion USD by 2025. Among these chiral molecules, β2-amino acids and their derivatives are highly demanding chemicals because of their extensive uses in the synthesis of pharmaceuticals. My SYNERGISTIC proposal will envisage the functionalization of challenging alkenes and CO2 to achieve chiral β2-amino acids under energy-efficient photocatalytic conditions. To achieve this chemistry, I propose a novel approach by employing two different catalysts to activate simultaneously the double bond of alkene and to insert CO2 into the double bond. I will use a metal-free photocatalyst in combination with a halogen atom transfer (XAT) reagent to activate the double bond of alkene, and a homogeneous chiral transition metal complex to insert the CO2 molecule in a face-selective way. The mild reaction conditions of photoredox catalysis should enable to functionalize a wide range of alkenes as well as for late-stage functionalization of ‘functionally challenging’ molecules found in natural products and complex pharmaceuticals. This proposal will significantly contribute to the advancement of the ‘CO2-valorization’ blueprint as well as will create a groundbreaking ‘green approach’ for the synthesis of chiral β2-amino acids using CO2 as a C1 synthon. More importantly, the fundamental new insights of this novel catalytic system that will be gained during this investigation will be a game-changer for the enhancement of sustainable chemistry.
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Duración del proyecto: 23 meses
Fecha Inicio: 2023-08-01
Fecha Fin: 2025-07-31
Fecha Fin: 2025-07-31
Línea de financiación: concedida
El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-08-01
Línea de financiación objetivo
El proyecto se financió a través de la siguiente ayuda:
HORIZON-MSCA-2022-PF-01-01:
MSCA Postdoctoral Fellowships 2022
Cerrada
hace 2 años
Líder del proyecto
UNIVERSITAT BAYREUTH
No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico
TRL
4-5
Perfil tecnológico
TRL
4-5