ReconsolidationDynamics
Financiado
A Cross Species Investigation of Memory Replay During Reconsolidation
A primary treatment for anxiety disorders is exposure therapy, which is based on the principles of extinction, but has the drawback that fear can return. This risk of relapse highlights a need for treatments that persist. Research...
A primary treatment for anxiety disorders is exposure therapy, which is based on the principles of extinction, but has the drawback that fear can return. This risk of relapse highlights a need for treatments that persist. Research on reconsolidation has shown that upon reactivation old fear memories can be updated, preventing the return of fear. However, studies targeting reconsolidation to reduce fear have reported mixed results because its boundary conditions are poorly understood. To live up to its clinical potential it is necessary to understand how to most effectively utilize paradigms targeting reconsolidation. The proposed research attempts to address this issue by providing a neural measure of the reconsolidation process itself. This will be achieved by determining whether dynamic patterns of neural network activity that occur during initial learning re-occur during offline ‘rest’ periods, and test whether this ‘replay’ of memory is linked to reconsolidation. The first objective of this grant application is to identify and quantify a neural marker of reconsolidation that predicts the absence of fear recovery. During the outgoing phase these questions will be addressed employing an innovative cross-species (humans, rats) approach using similar behavioural tasks, complementary recording techniques (functional magnetic resonance imaging, multi-unit recordings) and state-of-the-art analyses methods. Acquired knowledge and experience will be applied during the return phase where the second objective is to use this neural marker to determine how context serves as one critical boundary condition to inducing reconsolidation. Findings will significantly advance fundamental understanding of reconsolidation and have important implication for applied and preclinical psychiatric research.
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Duración del proyecto: 36 meses
Fecha Inicio: 2015-05-04
Fecha Fin: 2018-05-31
Fecha Fin: 2018-05-31
Línea de financiación: concedida
El organismo H2020 notifico la concesión del proyecto el día 2018-05-31
Línea de financiación objetivo
El proyecto se financió a través de la siguiente ayuda:
MSCA-IF-2014-GF:
Marie Skłodowska-Curie Individual Fellowships (IF-GF)
Cerrada
hace 10 años
Presupuesto
El presupuesto total del proyecto asciende a
243K€
Líder del proyecto
STICHTING RADBOUD UNIVERSITEIT
No se ha especificado una descripción o un objeto social para esta compañía.
Perfil tecnológico
TRL
4-5
Perfil tecnológico
TRL
4-5
1.02M€ |
Participante