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DECIPHER

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A computational framework to interpret the chemical language of the microbiome

"Humans, animals and plants are covered in microbes. Such microbiomes have a major impact on the health of their hosts and have been linked to traits like growth promotion, stress resilience, and diseases. However, the mechanisms... ver más

30/11/2025

1M€

Presupuesto del proyecto: 1M€

Líder del proyecto

WAGENINGEN UNIVERSITY No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

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Financiación concedida El organismo H2020 notifico la concesión del proyecto el día 2020-10-20

ERC-2020-STG: ERC STARTING GRANTS

I+D

Cerrada hace 5 años

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No hay información privada compartida para este proyecto. Habla con el coordinador.

2 Participantes

1.50M€ | Lider

CERANOR, S.A.

722.16K€ | Participante

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Duración del proyecto: 61 meses Fecha Inicio: 2020-10-20
Fecha Fin: 2025-11-30

Líder del proyecto

WAGENINGEN UNIVERSITY No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 1M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto "Humans, animals and plants are covered in microbes. Such microbiomes have a major impact on the health of their hosts and have been linked to traits like growth promotion, stress resilience, and diseases. However, the mechanisms underlying microbiome-host interactions remain poorly understood. Recent studies have shown that microbiome-associated phenotypes are often mediated by specific molecules, a ‘chemical language’ that enables microbes to interact with each other and with the host. The biosynthesis of these molecules is encoded in metabolic gene clusters (MGCs) that are subject to frequent horizontal transfer and are therefore highly strain-specific. Current computational methods for analysing microbiomes largely focus on comparative taxonomic analyses and generic metabolism, and overlook this complex ""chemical dialog"". Indeed, no adequate methods are available to systematically study the roles of MGCs in microbiomes. At the same time, metabolomics data from microbiomes are full of ‘dark matter’: unknown molecules that cannot be traced to their producers. Here, I propose to develop the first comprehensive computational framework to study the chemical language of the microbiome. In the past years, I have developed technologies that lay the foundation for this ERC project, including automated identification of MGCs, grouping them into families and annotating them using reference data. With DECIPHER, I will move my research to the next level, by developing new algorithms to link MGCs to their metabolic products and to predict their molecular and ecological functions in microbiomes. I will then apply this new framework in a systematic study of microbiome- associated phenotypes in plants and humans. Together, the innovations proposed here will fill a key gap in the analysis of microbiome function and pave the way toward precision-engineering of microbiomes with specific metabolic capabilities for designer soils and microbiome-based therapies."

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