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POPTex

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A completely biological and human tissue-engineered mesh produced from Cell-Asse...

A completely biological and human tissue-engineered mesh produced from Cell-Assembled extracellular Matrix (CAM) in vitro for the treatment of Pelvic Organ Prolapse (POP) Pelvic Organ Prolapse (POP) is a major medical issue for women. It is estimated that 1 in 10 women will undergo a surgery to treat POP during her lifetime. To provide mechanical support to the slipping organ, strong and stiff synt... ver más

31/07/2024

INSERM

150K€

Presupuesto del proyecto: 150K€

Líder del proyecto

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHER... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-07-31

ERC-2022-POC2: ERC PROOF OF CONCEPT GRANTS2 Objective:Objectives:

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Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

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No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

INSERM

150.00K€ | Lider

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Duración del proyecto: 18 meses Fecha Inicio: 2023-01-19
Fecha Fin: 2024-07-31

Líder del proyecto

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHER... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 150K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Pelvic Organ Prolapse (POP) is a major medical issue for women. It is estimated that 1 in 10 women will undergo a surgery to treat POP during her lifetime. To provide mechanical support to the slipping organ, strong and stiff synthetic meshes have been used. Transvaginal meshes are now withdrawn from the market in many countries due to high complication rates. Hence, there is a strong medical and societal need for breakthrough innovations. We propose a new paradigm targeting the fundamental problem of synthetic meshes, i.e., the foreign body reaction, by providing a completely biological, tissue-engineered mesh to treat POP. Our strategy is based on a unique, biological material: the Cell-Assembled extracellular Matrix (CAM) produced by cells in vitro. Robust CAM sheets are cut to produce yarn subsequently knitted into a mesh. In 12 months, this proof of concept (PoC) aims to deliver unambiguous experimental evidence that a CAM-based tissue-engineered mesh has the potential to become a relevant alternative surgical solution to treat POP. This project is divided in 2 main tasks: 1) Production and mechanical characterization of a human CAM mesh, and of an equivalent ovine mesh, with properties justifying a preclinical test. 2) In vivo validation of an allogenic CAM mesh in a female sheep model at 2 and 6 month. This PoC will provide: 1) Proof that a human CAM-based knitted mesh can have clinically relevant mechanical properties; 2) Demonstration that an ovine CAM mesh can be successfully implanted to treat POP in a clinically relevant, allogeneic, large animal model; 3) Direct comparison between the biointegration of an ovine CAM mesh setting and the inflammatory response to a synthetic mesh. Overall, this PoC will increase the technology readiness level of our product from 1-2 to 3-4 by validating the functionality and safety of CAM meshes in a relevant in vivo environment. These outcomes will lead us closer to clinical trials and support a commercial endeavor.

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