Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

SUITEX

Financiado

Cerrado

A completely biological and human tissue engineered sling produced from Cell Ass...

A completely biological and human tissue engineered sling produced from Cell Assembled extracellular Matrix CAM in vitro for the treatment of Stress Urinary Incontinence SUI Stress Urinary Incontinence (SUI) is a major medical issue affecting 1 in 5 women. Implantation of synthetic slings, made of knitted plastic monofilament, is the gold standard surgical treatment. They provide mechanical support to... ver más

30/06/2026

INSERM

150K€

Presupuesto del proyecto: 150K€

Líder del proyecto

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHER... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-10-16

ERC-2024-POC: ERC PROOF OF CONCEPT GRANTS Objective:ObjectivesThe ERC Proof of Concept Grants aim at facilitating exploration of the commercia...

I+D

Cerrada

0% 100% 100%

Características del participante

Este proyecto no cuenta con búsquedas de partenariado abiertas en este momento.

Información adicional privada

No hay información privada compartida para este proyecto. Habla con el coordinador.

1 Participantes

INSERM

150.00K€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Duración del proyecto: 20 meses Fecha Inicio: 2024-10-16
Fecha Fin: 2026-06-30

Líder del proyecto

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHER... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 150K€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Stress Urinary Incontinence (SUI) is a major medical issue affecting 1 in 5 women. Implantation of synthetic slings, made of knitted plastic monofilament, is the gold standard surgical treatment. They provide mechanical support to the urethra avoiding involuntary loss of urine on effort. However, they are associated with serious complications and some countries have already suspended their use. Hence, there is a strong medical and societal need for breakthrough innovations. The two fundamental problems of synthetic slings are the excessive hardness of the material and the foreign body reaction it creates. We propose a new paradigm by providing a non-living tissue-engineered sling that is soft, yet strong, as well as completely biological and human. Our strategy is based on a unique material: the Cell-Assembled extracellular Matrix (CAM) produced by fibroblasts in vitro. We can produce robust CAM sheets from human or ovine cells with similar properties. They are cut to produce threads subsequently woven into CAM slings. The potential of CAM slings to treat SUI will be demonstrated through 2 main tasks: 1) Development of human and ovine CAM slings with mechanical properties justifying a preclinical study. 2) In vivo validation of allogenic CAM slings in a female sheep model at 2 and 6 months. This PoC will: 1) Prove that human CAM slings can have clinically relevant mechanical properties; 2) Demonstrate that equivalent ovine CAM slings can be successfully implanted in a clinically relevant, allogenic, large animal model; 3) Show a superior integration of ovine CAM slings compared to synthetic slings (reduced immune response and positive remodeling). Overall, this PoC will increase the technology readiness level of our product from 1-2 to 3-4. These outcomes will justify an expanded in vivo analysis and support a commercial endeavor targeting clinical application.

Conecta tu I+D

Entra hoy

¿Olvidó su contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores