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4-DBR

Financiado

4-Deep Brain Reconstruction

The 4-Deep Brain Reconstruction, 4-DBR consortium aims at generating a brand-new technological approach to regenerate brain affections that occurs in neurological disorders. With 180 million affected people and an economic burden... ver más

31/08/2025

FUNDACIO CLINIC PE...

3M€

Presupuesto del proyecto: 3M€

Líder del proyecto

FUNDACIO CLINIC PER A LA RECERCA BIOMEDICA No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5 | 650K€

Ver 6 Participantes

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2022-08-03

HORIZON-EIC-2021-PATHFINDEROPEN-01-01: EIC Pathfinder Open 2021 Scope:You should apply to this call if you are looking for support from EIC Pathfinder Open to reali...

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Cerrada hace 3 años

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6 Participantes

FUNDACIO CLINIC PER A LA REC...

729.50K€ | Lider

POIETIS

510.03K€ | Participante

VERIGRAFT AB

489.21K€ | Participante

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Duración del proyecto: 36 meses Fecha Inicio: 2022-08-03
Fecha Fin: 2025-08-31

Líder del proyecto

FUNDACIO CLINIC PER A LA RECERCA BIOMEDICA No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5 | 650K€

Presupuesto del proyecto 3M€

Descripción del proyecto The 4-Deep Brain Reconstruction, 4-DBR consortium aims at generating a brand-new technological approach to regenerate brain affections that occurs in neurological disorders. With 180 million affected people and an economic burden of 798 billion euros/year, Europe needs a radical leap in the future. The complexity of the human brain has condemned every past attempt at regeneration because incomplete technologies did not allow for a full recapitulation of the brain properties and any one of them missing jeopardized the functionality of the whole. There can't be any incremental solution for brain damage, the technology must be all-in. 4-DBR will focus on developing an implantable 4D reconstructed brain able to recapitulate all brain properties: a complex architecture of neuronal cells integrated in a complete blood circuitry, that will be complemented with an integrated opto-stimulator to induce correct specification and integration of neurons. 4-DBR integrates 6 technological leaders from complementary fields who will unite to develop the components of reconstructed-brains: laser-assisted bioprinting of pre-differentiated neurons with their native decellularized brain matrix, extrusion bioprinting of vascular system, in vitro blood-brain-barrier reconstruction and a tissue integrated wireless-controlled stimulating optoelectrical chip. These 4 components will then be combined into a transplantable reconstructed brain that will be tested in a small animal model of Huntington’s disease. While a first prototype will be delivered in 36 months, the vision unifying 4-DBR expands way further. Therefore, the project will put into action a strong dissemination and exploitation plan: horizontally, 4-DBR will ensure the uptake of the generated methods to strengthen Europe’s technological actors; vertically, 4-DBR will thrust the reconstructed brain approach up in the development ladder to potentially generate in a 10-year span a therapy to change the lives of many patients.

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