Hola,
¿eres nuevo aquí?

Regístrate gratis y conecta tu empresa con financiación pública, partners y proyectos.

Tengo cuenta

Regístrate

Ver video

3NTHESES

Financiado

3D-printed boNes and Tendon-inspired Hierarchical Electrospun Scaffolds strategi...

3D-printed boNes and Tendon-inspired Hierarchical Electrospun Scaffolds strategies to enhance the Enthesis regeneration via Stem cells 3NTHESES will bring together innovative additive manufacturing (AM) and electrospinning (ES) biofabrication strategies, to produce a new generation of multi-layer hierarchical multi-material scaffolds (MLHMMS) able to faithfully m... ver más

30/09/2024

UNIVERSITEIT MAAST...

188K€

Presupuesto del proyecto: 188K€

Líder del proyecto

UNIVERSITEIT MAASTRICHT No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-09-30

HORIZON-MSCA-2021-PF-01-01: MSCA Postdoctoral Fellowships 2021 ExpectedOutcome:

I+D

Cerrada hace 3 años

0% 100% 100%

1 Participantes

UNIVERSITEIT MAASTRICHT

187.62K€ | Lider

Conecta tu I+D

¿Tienes un proyecto y buscas un partner? Gracias a nuestro motor inteligente podemos recomendarte los mejores socios y ponerte en contacto con ellos. Te lo explicamos en este video

Proyectos interesantes

SAF2017-83118-R ARQUITECTURAS POLIMERICAS 3D ACTIVAS PARA MEDICINA REGENERAT... 127K€ Cerrado

PersonalBone Multifunctional Personalized Self Assembled Biomaterials for... 1M€ Cerrado

FJC2019-039925-I Development of 3D printed biodegradable scaffolds for tissue... 50K€ Cerrado

MAT2015-65601-R NUEVAS ESTRATEGIAS DE BIOIMPRESION PARA REGENERACION OSEA Y... 339K€ Cerrado

RTI2018-096088-J-I00 MATRICES TERAPEUTICAS IMPRESAS EN 3D BASADAS EN SILICE QUE M... 157K€ Cerrado

DPI2017-88465-R MEJORA DE LA BIOFUNCIONALIDAD DE SCAFFOLDS POLIMERICOS OBTEN... 218K€ Cerrado

Duración del proyecto: 26 meses Fecha Inicio: 2022-07-29
Fecha Fin: 2024-09-30

Líder del proyecto

UNIVERSITEIT MAASTRICHT No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 188K€

Descripción del proyecto 3NTHESES will bring together innovative additive manufacturing (AM) and electrospinning (ES) biofabrication strategies, to produce a new generation of multi-layer hierarchical multi-material scaffolds (MLHMMS) able to faithfully mimic the multiscale morphology and the mechanical performances of the enthesis tissue. MLHMMS will be designed to drive the stem cells fate. Starting from the morphological study of an animal model, several imaging techniques will be used to acquire and measure all the morphological features of the tendon, the fibrocartilage and the bone tissue. The bone images will be used to produce bone-inspired AM mineralized scaffolds that will be directly printed on ES hierarchical nanofibrous tendon-inspired partially mineralized scaffolds, reproducing the whole enthesis. The mechanical performances of the MLHMMS will be compared with the natural tissue using mechanical tests matched with imaging strain analysis. The optimized MLHMMS, will be seeded with stem cells in comparative static and dynamic cultures in bioreactor following their proliferation, differentiation in tenocyte, fibrochondrocytes, osteocytes and the production of different biological markers, using imaging and biological characterizations. Finally, the cellularized constructs will be mechanically compared with the natural tissue using biomechanical tests. The applicant (Dr. Alberto Sensini) is a research fellow in biofabrication and biomechanics. He will apply the tendon-inspired ES hierarchical scaffold, developed during his Ph.D., and his imaging/biomechanical skills to enhance the biomimicry of these constructs. Moreover, thanks to the supervision, mentoring and training activities provided by the host organization (Maastricht University) on bone AM, stem cells cultures and biological characterizations, he will complete his interdisciplinary biofabrication expert profile.

Conecta tu I+D

Entra hoy

¿Olvidé mi contraseña?

Financiación

Empresas

CTIs/Universidades

Proyectos

Investigadores