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3DSecret

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3D spheroids derived from single cells for discovering stochastic patterns behin...

3D spheroids derived from single cells for discovering stochastic patterns behind metastasis Metastasis remains accountable for 9 out of 10 fatalities within cancer disease. However, the mechanisms governing the onset of metastasis are far from being fully understood. Notably, metastases are predominantly clonal and arise... ver más

31/12/2026

LABORATORIO IBERIC...

3M€

Presupuesto del proyecto: 3M€

Líder del proyecto

INTERNATIONAL IBERIAN NANOTECHNOLOGY LABORATO... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2023-01-01

HORIZON-EIC-2022-PATHFINDEROPEN-01-01: EIC Pathfinder Open 2022 Scope:You should apply to this call if you are looking for support from EIC Pathfinder Open to reali...

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Cerrada hace 2 años

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Duración del proyecto: 47 meses Fecha Inicio: 2023-01-01
Fecha Fin: 2026-12-31

Líder del proyecto

INTERNATIONAL IBERIAN NANOTECHNOLOGY LABORATO... No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Presupuesto del proyecto 3M€

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Metastasis remains accountable for 9 out of 10 fatalities within cancer disease. However, the mechanisms governing the onset of metastasis are far from being fully understood. Notably, metastases are predominantly clonal and arise from a single cell. 3DSecret will investigate metastasis from a radically new perspective, with the overarching goal of unravelling stochastic patterns at the single-cell level with predictive and prognostic capacity. Critically, defining the hallmarks of metastasis from holistic studies of single circulating tumour cells (CTCs), thus dissecting tumour heterogeneity, has the power to revolutionise cancer treatment and diagnosis. This will pave the way for game-changing discoveries in what is one of the holy grails of modern clinical science. To achieve our goal, 3DSecret will use a set of key enabling technologies including microfluidics, nanosensors, genomics, and artificial intelligence (AI). Microfluidics will drive the isolation of single CTCs from whole blood samples of 60+ metastatic breast cancer patients. These will be grown on-chip to form 3D spheroids, thus allowing comprehensive genomic and transcriptomic studies of single-cell origin while bypassing the errors typically introduced by single-cell genome amplification. The genomic and transcriptomic data will be combined with clinical information, single-cell growth profiles and dynamic metabolomic analyses obtained by the use of nanosensors and SERS, to develop a multimodal AI analytical tool capable of identifying unknown patterns driving metastasis. The bold assumption that there could be stochastic patterns driving metastasis, cancer evolution and malignancy, makes the approach of 3DSecret exceptionally high-risk, high-gain. We are confident that such a breakthrough would lead to a major paradigm shift with significant implications in biology, physics, disruptive technologies such as AI, and critically, in the medical arena and patient care.

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