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TissueEng

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3D bioprinting construct for the diminishing of bone tumor and progression of bo...

3D bioprinting construct for the diminishing of bone tumor and progression of bone tissue regeneration: Diagnosis of phenotyping in the cellular model and screening as a therapeutic platform Bone tissue engineering has been considered a viable solution Bone tissue engineering has been considered a viable solution for clinical restoration and recovery of defected bone tissue caused by injuries, skeletal dysfunction, an... ver más

28/02/2027

UAveiro

Presupuesto desconocido

Líder del proyecto

UNIVERSIDADE DE AVEIRO No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite participación Sin fecha límite de participación.

Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto

HORIZON-WIDERA-2023-TALENTS-02-01: ERA Fellowships ExpectedOutcome:This action builds on the MSCA Postdoctoral Fellowships 2023 action (HORIZON-MSCA-PF...

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UAveiro

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Duración del proyecto: 23 meses Fecha Inicio: 2025-03-01
Fecha Fin: 2027-02-28

Líder del proyecto

UNIVERSIDADE DE AVEIRO No se ha especificado una descripción o un objeto social para esta compañía.

TRL 4-5

Fecha límite de participación Sin fecha límite de participación.

Descripción del proyecto Bone tissue engineering has been considered a viable solution Bone tissue engineering has been considered a viable solution for clinical restoration and recovery of defected bone tissue caused by injuries, skeletal dysfunction, and cancer. But current approaches are limited in developing cellular disease models to screen the target genes in tumour relapsing, which enables finding suitable preclinical strategies (animal model). The project will use 3D bioprinting to create an external field driving biosensor-impregnated 3D construct as a potential therapeutic platform for screening bone tumour behaviours and multidisciplinary approaches to bone defect recovery. Hence, the main objective is to determine if the formulation of chiro-magnetic nano-assembly incorporated electro-conductive hydrogel will be able to mimic the in vivo disease model to identify the target of expression in the osteosarcoma model, which will enable the finding of an effective therapeutic strategy for osteosarcoma treatment with gender diversity. The project will focus on the multidisciplinary approach (material science, biochemistry, and cell biology) in the formulation of the multifunctional 3D bioprinting hydrogel (visible light based photo-cross-linkable). The 3D construct will have tunable physical properties such as mechanical stability, chiro-magnetic, etc in determining all stages of cellular behaviour; magnetothermal activity in killing tumour cells; and electro-stimulation mediated osteointegration in tissue regeneration. The project will include the transfer of the candidate’s knowledge to the host and acquiring extensive training from UAveiro on advanced tools and techniques as a part of the career development plan. The results will have a potential impact on humankind and patients from all socio-economical levels, and they are in line with the EU mission to have a significant economic impact on the sustainability of public healthcare care for low-to medium-earning patients' families.

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