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2D-NanoHyb

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2D Nano Hybrid Systems interfacing biomolecular motors with nanopores in 2D mat...

2D Nano Hybrid Systems interfacing biomolecular motors with nanopores in 2D materials Interfacing the solid-state electronics with biological systems has been a long-standing challenge in nanobiotechnology. Creating nanobio hybrids would enable harnessing the remarkable capabilities offered by solid-state materials... ver más

31/08/2026

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146K€

Presupuesto del proyecto: 146K€

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Financiación concedida El organismo HORIZON EUROPE notifico la concesión del proyecto el día 2024-06-25

HORIZON-WIDERA-2023-TALENTS-02-01: ERA Fellowships Expected Outcome:This action builds on the MSCA Postdoctoral Fellowships 2023 action (HORIZON-MSCA-P...

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ECOLE POLYTECHNIQUE FEDERALE...

INSTITUT ZA FIZIKU

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Duración del proyecto: 26 meses Fecha Inicio: 2024-06-25
Fecha Fin: 2026-08-31

Líder del proyecto Líder desconocido

Presupuesto del proyecto 146K€

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Descripción del proyecto Interfacing the solid-state electronics with biological systems has been a long-standing challenge in nanobiotechnology. Creating nanobio hybrids would enable harnessing the remarkable capabilities offered by solid-state materials and biological molecules, such as proteins, enzymes, DNA etc., at the same time. Two-dimensional (2D) materials are among the most prospective building blocks for future-generation electronic and biosensing devices due to their exceptional optoelectronic and mechanical properties combined with their atomic thickness. Their ultimate thinness has been considered as a remarkable advantage for nanopore-based sensing, and they have been widely investigated as 2D solid-state nanopore platforms for single-molecule sensing. The goal of this proposal is to push further the development of 2D nanopores by developing new protocols for creating interfaces between 2D materials and biomolecular motors. Attaching the enzyme motor, such as DNA helicase, to a nanopore made in 2D material would introduce an active control in nanofluidic transport of single-molecules and ions. Such hybrid platforms presents a step forward in uniting biological inspiration and nanoscale engineering, offering unprecedented levels of control, precision, and versatility at the nanoscale. The future direction holds promise across a wide spectrum of applications, from fundamental scientific research to transformative technologies that could impact fields as diverse as nanobiotechnology, personalized medicine and diagnostics, environmental sensing, nanorobotics, and many more.

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