18F Fluorination of alkylCF3 and alkylCF2CF3 chains Application to hypoxia biom...
18F Fluorination of alkylCF3 and alkylCF2CF3 chains Application to hypoxia biomarkers for PET imaging.
The first objective of this proposal is to provide a solution to a well recognized problem in 18F-radiochemistry: the direct [18F]fluorination of trifluoromethylated and perfluorinated (CF2-CF3) alkyl chains. We propose to investi...
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Información proyecto HYPOXFLU
Duración del proyecto: 23 meses
Fecha Inicio: 2015-04-07
Fecha Fin: 2017-03-15
Fecha límite de participación
Sin fecha límite de participación.
Descripción del proyecto
The first objective of this proposal is to provide a solution to a well recognized problem in 18F-radiochemistry: the direct [18F]fluorination of trifluoromethylated and perfluorinated (CF2-CF3) alkyl chains. We propose to investigate a copper-mediated fluorination of alkyl boronic species using [18F]fluoride. The value of this new radiochemistry will be challenged with the synthesis and the labelling of two well-known and promising biomarkers for hypoxia, EF3 and EF5. We propose to develop an automated protocol for the production of their radiolabelled counterparts, and to perform a pre-clinical comparative study of [18F]EF3 and [18F]EF5 with [18F]FMISO, the current hypoxia biomarker used for PET imaging.